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Fasting & Muscle Loss: 7 Day Fasting Study on Strength & Exercise Performance

by Mike Mutzel

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Let's discuss a new 7 day fasting study reviewing how fasting impacts muscle mass, strength and fat loss.

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Research Mentioned:

Kolnes, K. J. et al. Effects of seven days’ fasting on physical performance and metabolic adaptation during exercise in humans. Nat. Commun. 16, 122 (2025).

Time Stamps:

 

(00:00) – Introduction to Fasting and Exercise:
Overview of a study exploring the effects of seven days of fasting on muscle strength and athletic performance. Study details, including participant weight loss and questions about lean mass composition.

(00:55) – Key Findings on Muscle Strength and Performance:
Muscle strength remained unchanged, but oxygen uptake decreased by 13%. Discussion of glycogen depletion and metabolic adaptations during fasting.

(01:56) – The Role of Exercise in Health and Fasting Benefits:
Highlighting the importance of exercise for overall health, longevity, and enhanced fasting results. Introduction to Creapure creatine paired with electrolytes to optimize workouts.

(02:48) – Fasting, Exercise, and Autophagy:
Discussion on how regular exercise amplifies fasting benefits like autophagy and fat burning, referencing a study comparing active and inactive individuals during fasting.

(03:44) – Fasting’s Impact on VO2 Max and High-Intensity Performance:
Analysis of fasting’s effect on VO2 max and performance in high-intensity activities. Insights into metabolic shifts favoring fat usage over carbohydrates during fasting.

(05:27) – Weight Loss and Muscle Changes During Fasting:
Exploring muscle glycogen depletion, weight loss composition, and significant findings from DEXA scans, including muscle and bone mass changes.

(06:26) – Short-Term Strength vs. High-Intensity Endurance:
Why short-term strength is less impacted during fasting, but high-intensity endurance suffers due to glycogen depletion. Reflections on practical implications for athletes.

(07:17) – Sustainable Weight Loss and Final Thoughts:
Recommendation to prioritize consistent exercise, a balanced diet, and moderation over extreme fasting for sustainable health. Encouragement to share feedback and engage in the discussion.

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