A previous natural infection was associated with lower incidence of COVID-19 infection, regardless of the variant, than mRNA primary-series vaccination.
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Episode Time Stamps:
0:00 The study tracked comparison data between Feb 2020 and May of 2022.
2:00 Natural immunity occurs in the mucosal tissue where the virus enters your body and replicates.
2:12 Vaccines are given in the muscle and triggers your B cells and T cells to make immunologic memory to the spike protein.
3:15 With natural immunity you create immunologic memory to the entire virus, not just the spike protein.
6:15 People who had natural immunity had half the incidence of SARS COV2 reinfection over the course of the study.
6:40 Natural immunity led to 18.1 infections per 100K people vs Pfizer vaccinated people had 37.1 infections per 100K.
7:30 Natural immunity led to 16.7 infections per 100K people vs Moderna’s 32 infections per 100K people.
8:10 Previous natural infection was associated with lower incidence of SARS COV2 infection, regardless of the variant, than vaccines.
8:40 Immunity from the vaccine and natural immunity wanes with time.
10:35 Survivors of the first SARS outbreak and MERS outbreak in the early 2000s, had immunity 20 years later. Survivors of the Spanish flu had immunity 90 years later.
14:00 95% of Americans have likely been exposed to the virus.
Chemaitelly, H. et al. Protection from previous natural infection compared with mRNA vaccination against SARS-CoV-2 infection and severe COVID-19 in Qatar: a retrospective cohort study. Lancet Microbe 3, e944–e955 (2022).