Let's discuss how different macronutrients and blood sugar issues can regulate aging and the induction of cellular senescence. We also discuss how various dietary interventions can achieve prevention of disease and extension of lifespan by modulating senescence.
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Nehme, J., Altulea, A., Gheorghe, T. & Demaria, M. The effects of macronutrients metabolism on cellular and organismal aging. Biomed J (2023) doi:10.1016/j.bj.2023.02.005.
Chaib, S., Tchkonia, T. & Kirkland, J. L. Cellular senescence and senolytics: the path to the clinic. Nat Med 28, 1556–1568 (2022).
00:25 Cellular senescence accelerates biologic ageing.
02:00 Senescent cells are enlarged, have dysfunctional mitochondria, and release pro-inflammatory signaling molecules.
02:30 Senescence manifests as wrinkles, memory loss, muscle loss, gray hair, fatty liver, excessive visceral adipose tissue.
03:45 Senescence occurs in response to stressors or developmental signals and behave similar to cancer cells.
05:45 Dysfunctional mitochondria influences glycolysis in cells.
06:15 Give your cells less fuel, glucose, for the proliferation of inflammation.
07:45 Hyperglycemia decreases nitric oxide, which helps prevent cellular senescence.
08:00 Sirtuins can inhibit the formation of senescent cells.
08:55 Berberine, Metformin, and low dose rapamycin, have been used to mitigate hyperglycemia.
10:30 Hyperglycemia also impacts your cardiovascular system and endothelial cells.
12:00 Fat cells can become senescent.
13:00 Ketones (BHB) can help inhibit cellular senescence.
13:25 Optimized omega 3 to omega 6 ratio can help.
14:00 Exercise counters age-related accumulation of senescent cells.
14:40 Senescence within your immune cells is linked with cancer and poor response to infection.