Berberine is a natural product that’s been used in Chinese medicine for over 3,000 years.
Scientists recently found berberine can decrease arterial plaque in the carotid artery by some 3.2% after 16 weeks of use.
They write, “…21 patients with atherosclerosis exhibited the average decrease of plaque score by 3.2% after oral BBR (500 mg, twice daily) for 4 months (*P < 0.05, n = 21).
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Links to studies and videos mentioned:
Ma, S.-R. et al. Berberine treats atherosclerosis via a vitamine-like effect down-regulating Choline-TMA-TMAO production pathway in gut microbiota. Signal Transduct Target Ther 7, 207 (2022).
Cheng, H., Liu, J., Tan, Y., Feng, W. & Peng, C. Interactions between gut microbiota and berberine, a necessary procedure to understand the mechanisms of berberine. J Pharm Analysis 12, 541–555 (2022).
Patel, P. A bird’s eye view on a therapeutically ‘wonder molecule’: Berberine. Phytomedicine Plus (2021).
Episode Time Stamps:
00:00 Berberine has been used in medicine for 3,000 years.
00:23 Berberine treats atherosclerosis.
00:52 Berberine has been shown to regress plaque by 3.8% over 16 weeks.
01:14 Berberine has been used to treat bacterial-caused diarrhea.
01:34 It is a safe and effective treatment for hyperlipidemia treatment and type 2 diabetes.
02:14 Study dose 500 mg 2 times per day.
03:34 A reduction in TMAO was shown in a mouse study.
05:24 Berberine acts on intestinal bacteria.
07:04 Berberine may upregulate LDL receptors on the liver.