Blood Sugar

How Blood Sugar Imbalances Alter Collagen Production, Accelerates Aging of Your Skin, Joints

by Mike Mutzel


Poor metabolic health alters collagen production, accelerating the aging of skin as well as leading to joint pain and tendon problems.




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Study Mentioned:


Vaidya, R., & Lake, S. P. (2022). Effect of Diabetes on Tendon Structure and Function: Not Limited to Collagen Crosslinking. Journal of Diabetes Science and Technology.
Hamlin, C. R., Kohn, R. R., Diabetes, J. L.,. (1975). Apparent accelerated aging of human collagen in diabetes mellitus. Am Diabetes Assoc, 24(10).


Hastings, M. K., Jeong, H.-J., Sorensen, C. J., Zellers, J. A., Chen, L., Bohnert, K. L., et al. (2020). Relationships within and between lower and upper extremity dysfunction in people with diabetes. The Foot, 44, 101680.


Episode Time Stamps:


01:44 Elevated levels of blood sugar and poor metabolic health creates the formation of advanced glycation end products within the collagen matrix.

02:45 Age related changes are accelerated by the formation of glycated collagen.

03:25 An elevated hemoglobin A1C could indicate that your collagen peptides in your joints, skin, hair, and nails may be glycated.

05:03 Poor metabolic health instigates changes at a cellular level within collagen production and stem cell generation.

05:20 Diabetes affects collagen sliding and disorganization of collagen.

09:00 Advanced glycation end products are created when glucose attaches to proteins, changing the structure of the protein. Structure equals function.

10:00 Glycating of collagen peptides leads to a reduction in elasticity and the thickening of tendons.

10:45 When you lose weight, osteoarthritis improves, partly because inflammation has been reduced.

13:00 There can be more fat deposition and changes in mineralization within the tendon/collagen.

13:10 Take vitamin K with your vitamin D, so calcium is deposited in bones, not soft tissue.

13:37 There is reduction in type 1 and type 2 collagen peptide production and reduction in stem cells, because of glycation.

14:46 Hemoglobin A1C is a direct measure of glycation. Over 5.5% may indicate that your collagen may glycated as well.

15:25 Triglycerides (over 80), liver enzymes, fasting insulin, or fasting glucose elevations are other indicators of possible glycation.

17:13 Circadian rhythm is important for blood sugar control.

17:30 Berberine hydrochloride can improve gut hormones and improve metabolic health.


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