Semaglutide aka Ozempic is a GLP-1 agonist that's been around for a long time, suddenly Hollywood elites are now promoting it for fat loss. Here's the science you need to know.
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Wilding, J. P. H. et al. Once-Weekly Semaglutide in Adults with Overweight or Obesity. New Engl J Med 384, 989–1002 (2021).
Sharma, D., Verma, S., Vaidya, S., Kalia, K. & Tiwari, V. Recent updates on GLP-1 agonists: Current advancements & challenges. Biomed Pharmacother 108, 952–962 (2018).
0:20 Semiglutide is a GLP-1 agonist.
00:30 GLP-1, glucagon like peptide 1, functions under the category of gastrointestinal incretin hormones that helps you process the foods you eat. It improves insulin sensitivity. Decreases glucagon.
01:30 About 80% of the mechanisms of bariatric surgery is by amplifying the release of incretin hormones.
02:00 There was a 14% loss of body weight in study participants.
02:50 Semiglutide exerts stress on pancreatic beta cells, with an increased prevalence of pancreatitis and potentially pancreatic cancer.
04:40 GIP and GLP-1 are released after eating to increase insulin secretion from beta cells and prevent post-meal glucose excursions.
05:50 The diminished activity of GIP and GLP-1 is a feature of type-2 diabetes, beta cell insulin resistance, an obesity.
07:10 Exercise increases the release of gastrointestinal incretin hormones.
07:25 Berberine increases gut hormones and changes your microbiome.
07:40 These incretin hormones control the ecosystem of your gut microbiome and can improve function of immune cells around your gut.
08:10 Bifidobacterium can lead to a healthier GI incretin response.
09:00 GABA and L-glycine.
09:45 Protein and fat.