Seed Oils and Your Brain

Let's review the available data about how seed oils impact your brain, cognition and more.

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Research:

Kris-Etherton PM, Taylor DS, Yu-Poth S, Huth P, Moriarty K, Fishell V, Hargrove RL, Zhao G, Etherton TD. Polyunsaturated fatty acids in the food chain in the United States. Am J Clin Nutr. 2000 Jan;71(1 Suppl):179S-88S. doi: 10.1093/ajcn/71.1.179S. PMID: 10617969.

Ramsden CE, Domenichiello AF, Yuan ZX, Sapio MR, Keyes GS, Mishra SK, Gross JR, Majchrzak-Hong S, Zamora D, Horowitz MS, Davis JM, Sorokin AV, Dey A, LaPaglia DM, Wheeler JJ, Vasko MR, Mehta NN, Mannes AJ, Iadarola MJ. A systems approach for discovering linoleic acid derivatives that potentially mediate pain and itch. Sci Signal. 2017 Aug 22;10(493):eaal5241. doi: 10.1126/scisignal.aal5241. PMID: 28831021; PMCID: PMC5805383.

Mercola, J., & D'Adamo, C. R. (2023). Linoleic Acid: A Narrative Review of the Effects of Increased Intake in the Standard American Diet and Associations with Chronic Disease. Nutrients, 15(14), 3129. https://doi.org/10.3390/nu15143129

Ginsberg, H. N., Karmally, W., Barr, S. L., Johnson, C., Holleran, S., & Ramakrishnan, R. (1994). Effects of increasing dietary polyunsaturated fatty acids within the guidelines of the AHA step 1 diet on plasma lipid and lipoprotein levels in normal males. Arteriosclerosis and thrombosis : a journal of vascular biology, 14(6), 892–901. https://doi.org/10.1161/01.atv.14.6.892

Marklund, M., Wu, J. H. Y., Imamura, F., Del Gobbo, L. C., Fretts, A., de Goede, J., Shi, P., Tintle, N., Wennberg, M., Aslibekyan, S., Chen, T. A., de Oliveira Otto, M. C., Hirakawa, Y., Eriksen, H. H., Kröger, J., Laguzzi, F., Lankinen, M., Murphy, R. A., Prem, K., Samieri, C., … Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Fatty Acids and Outcomes Research Consortium (FORCE) (2019). Biomarkers of Dietary Omega-6 Fatty Acids and Incident Cardiovascular Disease and Mortality. Circulation, 139(21), 2422–2436. https://doi.org/10.1161/CIRCULATIONAHA.118.038908

Show Notes:

00:00 Linoleic acid, from dietary seed oils, is in your fat cells.

01:30 25% of total fatty acids in your fat tissue comes from linoleic acid.

01:55 Seed oils are prone to oxidization.

02:30 Soy, cotton seed, corn, canola, and sunflower oil are in most processed foods.

06:00 We eat less eggs, milk, beef and pork, and more chicken.

07:20 The half-life of linoleic acid in adipose tissue is 680 days.

08:15 Increasing body fat increases inflammation and insulin resistance.

09:00 Linoleic acid worsens inflammation and insulin resistance.

10:00 Diets rich in omega 6 fatty acids are associated with depression, poor mental health, pain, peripheral nerve damage, IBS, arthritis, and headaches.

12:55 Omega 3 fats are associated with reduced pain.