Connect with Paul:
03:17 Physical connection is indispensable for humans. Face masks create a loss of intimacy.
07:35 Outdoor transmission of Corona virus is virtually zero.
08:03 Masks are not designed to prevent the transmission of viruses. Masks do not prevent air flow coming in or out, unless it is an N95. N95 does not allow as much air flow, but should not be worn all day.
09:55 People suffering most from the virus have metabolic dysfunction: diabetes, insulin resistance. The virus will travel throughout our population. Most of us will be exposed. The question is when.
16:18 Insulin plays a role in immune response. Immune cells of the innate and adaptive immune system have receptors for insulin. When you are insulin resistant, insulin signaling does not proceed adequately in muscle, pancreas, liver, brain, T cells, B cells, natural killer cells, neutrophils or macrophages.
18:05 The balance and cooperation between the innate and the adaptive immune systems is disordered in metabolic dysfunction.
22:05 In order to generate antibodies from a vaccine, you need a concert of innate and adaptive immune systems. A vaccine for Corona virus is a band aide for those of us with metabolic dysfunction because we are vulnerable to many other things.
28:31 The NLRP3 inflammasome is overactivated in metabolic disorders.
29:10 Insulin is a master hormone. It controls blood sugar regulation, lipolysis at the level of the adipocyte, and it controls and directs the immune system.
33:34 Ageing is accelerated by insulin resistance. Ageing can be accelerated, decelerated or reversed with lifestyle. We don’t need super drugs.
37:47 Most times, it is insulin resistance leading to inflammation. Autoimmune conditions can cause insulin resistance.
40:00 Antinutrients in vegetables can drive inflammation and in turn, insulin resistance.
41:20 Vegetable oils, like linoleic fatty acid and steric fatty acid, have profound metabolic signaling effects. The half life for some polyunsaturated fatty acids is more than 1 ½ years or 2 years. We receive fat soluble hormones when we eat vegetable oils or animals fed corn or soy. These can stay in the body with a signaling effect for maybe 2 years after you stopped eating it in excess amounts.
44:10 Metformin changes mitochondrial metabolism.
44:55 Leptin is a metabolic and immune hormone that is linked with autoimmune disease.
46:30 Steric acid, is present in cacao butter and suet (kidney fat).
49:11 Polyunsaturated fatty acid in human adipose tissue has increased over 135% in last 60 to 70 years. The majority of our excess polyunsaturated fatty acids are linoleic acid.
49:30 Vegetable oil was sold starting in 1865. Humans have been eating animal fats for hundreds of thousands of years.
51:40 The more saturated an oil is, the more susceptible it is to oxidation or peroxidation.
52:08 Excess consumption of omega 3 as fish oil supplements may lead to increased lipid peroxidation products.
53:14 DHA/arachidonic acid ratio in the brain of developing infants can be disordered when mothers are consuming too much linoleic acid during gestation. Linoleic acid becomes incorporated into the brains of infants, displacing DHA.
54:30 Dietary steric acid regulates mitochondria in vivo in humans. Mitochondria turn on and begin beta oxidation from signaling from steric acid.
56:30 When we consume linoleic acid, levels increase in our blood and our fatty acid tissue. When you give humans or mitochondria linoleic acid, they become more insulin sensitive.
58:31 Visceral adipose tissue can be a main source of lipokine signals to the rest of the body whether to become insulin sensitive or insulin resistant.
58:53 If you cannot store any more fat in your viscera or subcutaneous adipose tissue, your body activates the ATGL enzyme. It spews free fatty acids to signal your body to become insulin resistant.
01:01:10 When fat becomes insulin sensitive, it expands. When we eat linoleic acid, it makes visceral adipose tissue and subcutaneous adipose tissue, insulin sensitive.
01:03:30 You want your adipocytes to be insulin resistant. You do this be eating saturated fat from animals.
01:08:00 Steric acid is not toxic to humans. It is an evolutionary signal that you have abundance.
01:09:32 Steric acid to linoleic acid ratio in humans. Two to 3 percent of human calories should come from linoleic acid. Get rid of your vegetable oils.
01:12:40 Grass fed ground beef or stew meat is less expensive than cuts. Buy in bulk to bring the price down. If you cannot get grass fed/grass finished beef, get the leanest meat you can find and get suet from the butcher. Suet is inexpensive.
01:15:10 Animal fat from Suet, tallow, and dairy are the best fat sources. Even better than coconut oil. Avocado oil can be cut with vegetable oil.
01:18:10 Chickens and pork store linoleic acid from corn and soy and pass it on to you. Ruminants fed corn and soy do not. They convert polyunsaturated fatty acids into saturated fats. We cannot do that.
01:16:32 Fat soluble pollutants will be more concentrated in cows fed grain.
01:17:23 DHA deficiency may be from linoleic acid excess. It may not be that we are not getting enough omega 3. It may be that we are getting too much linoleic acid. DHA deficiency in expectant mothers is a huge problem. You can either increase DHA or decreasing linoleic acid and eating whole foods.
01:19:02 The overwhelm strategy floods the body with polyunsaturated fatty acids, which may cause problems down the road with oxidative stress.High dose omega 3 is beneficial because we have so much omega 6, that we must overwhelm it.
01:19:49 A linoleic to DHA ratio is more helpful. Omega check panel will give a 3 to 6 ratio. Omega six will incorporate arachidonic acid, which is an important fat for the developing brain.
01:20:20 Linoleic acid below 18% in a red blood cell is preferred by Dr. Saladino.
01:22:40 The ratio of palmitate to palmitoleic acid coming from adipocytes is what tells your body to be insulin sensitive or resistant. Diabetics have high levels of palmitate, the saturated fat. When your adipocytes are over full, they excrete palmitate into the blood. Ingesting saturated fat does not increase the tissue level of palmitate.
01:29:30 Eat animal organ meats. It is preferred to taking supplements with organ meats in them.