Learn how the methylation pathway is linked to glutathione/antioxidant production to prevent free radicals (AKA oxidative stress) from damaging tissues and DNA.
– The methylation cycle is critical for making neurotransmitters, hormones, creatine, phospholipids, and for stabilizing DNA.
– Homocysteine is in equilibrium with S-adenosylhomocysteine, which blocks S-adenosylmethionine (SAMe) from passing on methyl groups.
– S-adenosylhomocysteine is actually more stable than homocysteine, which means that if homocysteine is high, then methylation will be inhibited.
– A high homocysteine generally suggests that sulfur groups are not being donated to make glutathione in the transsulfuration cycle (the cycle just below the methylation cycle).
– It’s been estimated that some 50 percent of glutathione’s precursors stem from sulfur groups that run through the methylation cycle.
-Impaired glutathione production leads to increased DNA damage as well as free radical and cell membrane stress.
– The methylation cycle is linked to both glutathione production and the free radical stress cycle.
– This “triad” needs to be supported simultaneously because if one aspect is off, it’s likely that so are others.