Let’s review a the long-known law of declining virulence which describes how viruses and parasites evolve to become less virulent over time as they infect more hosts.
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Brüssow, H. (2021). What we can learn from the dynamics of the 1889 “Russian flu” pandemic for the future trajectory of COVID-19. Microbial Biotechnology, 14(6), 2244–2253. http://doi.org/10.1111/1751-7915.13916
Mass vaccination produces a reduction in virus circulation, but also evolutive pressure towards the appearance of virus-resistant strains. We discuss the balance between these two effects, in particular when the mass vaccination takes place in the middle of an epidemic period.