Fasting and Autophagy for Weight Loss: Why Exercise is Important to Harness the Benefits

Exercise has been shown to benefit autophagy via a two-pronged approach:

1) Exercise is a direct autophagy enhancer (at least in muscle tissue).
2) People who regularly exercise have increased autophagy when they fast.

Referenced Article: 

Dethlefsen, M., Bertholdt, L., Gudiksen, A., Stankiewicz, T., Bangsbo, J., Hall, G., Plomgaard, P., Pilegaard, H. (2018). Training state and skeletal muscle autophagy in response to 36 h of fasting Journal of applied physiology (Bethesda, Md. : 1985) 125(5), 1609 – 1619. https://dx.doi.org/10.1152/japplphysiol.01146.2017

Autophagy Deep Dive with Peter Attia, MD: 

 

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Before you open up that bag of chips (out of boredom) have an ‘Exercise Snack’. As the dotted lines in the image above show, a small exercise snack lowers glucose and insulin and has additional benefits for fat mobilization and mental clarity 🔥🔥. P.S. @stanefferding @marksmellybell have been promoting this for a loooong time! #fitness #fatloss #10minwalk #hiit #snack #exercise #exercisesnack #exercisescience

A post shared by Mike Mutzel, MS (@metabolic_mike) on Aug 13, 2020 at 10:39am PDT