Gut Bacteria

#253 David Perlmutter, MD: Food DNA Cross-Talks with Gut Bacteria Influencing Our Metabolism

by Mike Mutzel



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    About David Perlmutter, MD

    David is a board-certified neurologist and a Fellow of the American College of Nutrition. He was the recipient of the Linus Pauling Award for his innovative approaches to neurological disorders. With his books now published in twenty-seven languages, Dr. Perlmutter is setting new standards for what healthy lifestyle means around the world. He is the author of the New York Times bestsellers Grain Brain, The Grain Brain Cookbook, and Brain Maker, as well as The Better Brain Book and Raise a Smarter Child by Kindergarten. He lives in Naples, Florida.


    Studies Mentioned:

    Teng, Y., Ren, Y., Sayed, M., Hu, X., Lei, C., Kumar, A., et al. (2018). Plant-Derived Exosomal MicroRNAs Shape the Gut Microbiota. Cell Host and Microbe, 1–26.

    Books Mentioned

    Grain Brain: The Surprising Truth about Wheat, Carbs, and Sugar–Your Brain's Silent Killers

    Seeds of Deception: Exposing Industry and Government Lies About the Safety of the Genetically Engineered Foods You're Eating

    Genetic Roulette: The Documented Health Risks of Genetically Engineered Foods

    Brain Maker: The Power of Gut Microbes to Heal and Protect Your Brain–for Life

    Belly Fat Effect: The Real Secret About How Your Diet, Intestinal Health, and Gut Bacteria Help You Burn Fat

    Related Content: #163: David Perlmutter, MD – Gut Bacteria, Carbohydrates and the Ketogenic Diet


    Show Notes

    05:00 The carnivorous diet is unlikely to have been followed by our ancestors.

    06:34 We need to nurture the gut with plant based foods and plant fiber and fewer animal products.

    06:48 There is no dietary fiber in meat. Fiber is one of the most underrated and most valuable food choices you can make. Make one meal a day plant based. High fiber is linked to good things happening to gut bacteria.

    07:47 Plant RNA influence the RNA of our bacteria. Dr. Teng at University of Louisville demonstrated that exosomes, small encapsulated cells from plants, contain plant RNA. Exosomes are released during digestion and incorporated into bacterial and influence their RNA expression. This influences the location of microorganisms, what they do and reproduction.

    08:44 What are GMOs doing to our DNA? Genetically modified plant genomes may have a larger impact upon us than previously thought. If consuming the plant affects our gut bacteria and our gut bacteria affect our genome.

    10:20 Our ancestors were in ketosis a significant amount of the time, research will probably confirm.  Food availability promoted ketosis. They also had no processed foods.  We are in some stage of ketosis before we eat breakfast.

    13:34 Food is information for your body. Humans suddenly, in evolutionary terms, shifted to a diet favoring carbohydrates.

    14:27 In 2 to 2.5 million years ago until the development of agriculture, the human brain increased in size 3 fold. Since the development of agriculture, the human brain has shrunken by 10%. This is correlative.

    14:56 Ancient ancestors had beautiful teeth. It is a surrogate marker for health and diversity of the oral microbiome. Agriculture may be responsible for our loss of bone density in poor dentition.

    18:47 Glucose levels in the 70 or 80s is optimal. One study showed chronic low insulin may lead to dementia, as does high insulin.

    20:10 Insulin plays a huge role in the health and functionality of the brain.

    22:12 Most wheat in America is sprayed with an herbicide called glyphosate, which negatively impacts the health and diversity of your gut bacteria. It alters the microbiome of the animals which we consume, making the animals more likely to become ill and require antibiotics.

    26:35 Weight of Americans continues to rise even though carbohydrate consumption is slightly declining. It may be the manifestation of major shifts that happened in the microbiome while we ate higher levels of simple carbohydrates.

    27:17 Weight is impacted by the use of artificial sweeteners that are not considered carbs. Drinking beverages artificially sweetened, increases your risk of diabetes greater than drinking one with regular sweetener. Artificial sweeteners compromise the health of your microbiome.

    28:00 When you taste sweet, it tells you that winter is coming and to store fat, stop fat burning fat and create more fat. It shifts your microbiome to one that senses caloric scarcity.

    31:26 Your behavior is dictated by the foods you eat. Higher blood sugars modify our proteins, increasing inflammation. Higher inflammation inhibit the connection between your primitive satisfaction brain center and the prefrontal cortex, allowing you to be thoughtful.

    33:40 Nature connectedness increases empathy, lowers cortisol and has a measurable effect on immune reactivity.

    39:05 Much olive oil in the US is adulterated with other oils, even high end restaurants. US canola oil is processed in a way that does not provide a healthy product. In addition, most is genetically modified.

    40:45 Food from genetically modified seeds has not been shown to be threatening. However, GMO foods may have absorbed glyphosate. Genes from GMO plant cells get into our body and our bacteria.

    45:08 Hope is not a strategy. So something. We are all planet shareholders. Learn as much as you can. Educate.

    47:11 A single course of antibiotics can make permanent changes in gut bacteria. 70% of antibiotic prescriptions are written for inappropriate reasons. Increase probiotic fiber. Remove threats to gut bacteria, like chlorinated water, poor sleep, and little exercise. There is a correlation between amount of aerobic exercise and the diversity of microbial species.

    51:21 Our brains are hardwired to look for sweet. Dopamine stimulates areas of the brain involved with opiates. Dopamine hits can become an addiction.  The dopamine receptor can be triggered by fast foods

    56:39 Dr. Perlmutter is writing another book called Brain Washed. It speaks to the change in the wiring of the human brain based upon external influences.

    59:55 Creativity is important in re-establishing connection to dormant parts of the brain.  Draw, write, learn a new musical instrument or language not just for novelty, but for creativity.

    01:01:15 Dr. Perlmutter’s motivation to persist to publish Grain Brain is due, in part, to his admiration of Thomas Edison’s persistence. Failure is a good teacher. Writing the book is a learning process.

    01:07:53 There is something every day that you can do to demonstrate how grateful you are, even something as little as picking up a piece of paper.


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