Calorie Deficits and Surpluses, mTOR, AMPK and Hormones

by Mike Mutzel





About This Video

In this new video, we review how nutrient-sensing enzymes that detect “energy balance” are also influenced by a range of non-nutritive factors, like hormones, inflammation and even oxygen levels.

If you’ve tried the “calorie balancing” approach for shedding some extra pounds and haven’t experienced satisfactory results, then you might want to look at the physiology behind weight gain.

Here are some takeaways from this podcast:

00:40 Hormones and energy balance are interconnected

01:30 mTOR as a primary energy sensor

02:51 How hormones influence and regulate energy switches

03:13 The anabolic vs catabolic balance (energy surpluses vs deficits)

03:52 How mTOR gets activated

04:51 Catabolic states, exercise and AMPK

05:40 Insulin, glucagon and malonyl-CoA: the triad that regulates fat synthesis and oxidation

07:10 The big picture of energy balance in the context of lifestyle change

I hope you’ll enjoy this deep dive into calorie deficiency,

Related Video: Putting an End to the Calorie Debate – Do Calories in Calories Out Matter?

Key Science Review Mentioned:

Laplante, M., & Sabatini, D. M. (2012). mTOR Signaling in Growth Control and Disease. Cell, 149(2), 274–293.

Products and Additional Resources:

Berberine HCL + ALA Complex | 500 mg of Berberine Per Serving

MCT to Go | Medium Chain Triglyceride Powder | Unflavored Keto Supplement | Travel-Friendly Stick-Packs

Leave a Reply