About This Video
In this new video, we review how nutrient-sensing enzymes that detect “energy balance” are also influenced by a range of non-nutritive factors, like hormones, inflammation and even oxygen levels.
If you’ve tried the “calorie balancing” approach for shedding some extra pounds and haven’t experienced satisfactory results, then you might want to look at the physiology behind weight gain.
Here are some takeaways from this podcast:
00:40 Hormones and energy balance are interconnected
01:30 mTOR as a primary energy sensor
02:51 How hormones influence and regulate energy switches
03:13 The anabolic vs catabolic balance (energy surpluses vs deficits)
03:52 How mTOR gets activated
04:51 Catabolic states, exercise and AMPK
05:40 Insulin, glucagon and malonyl-CoA: the triad that regulates fat synthesis and oxidation
07:10 The big picture of energy balance in the context of lifestyle change
I hope you’ll enjoy this deep dive into calorie deficiency,
Key Science Review Mentioned:
Laplante, M., & Sabatini, D. M. (2012). mTOR Signaling in Growth Control and Disease. Cell, 149(2), 274–293.