Autophagy, Fasting and the Ketogenic Diet: Science and Updates

by Mike Mutzel





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Tools That May Help Support Healthy Glucose and Lipid Metabolism* During Fasting and Ketosis:

MonoSorb 1300 | Extra Strength Fish Oil | 600 mg EPA | 260 mg DHA | Monoglyceride Form | IFOS Certified | Enteric Coated

Berberine HCL + ALA Complex | 500 mg of Berberine Per Serving


What Others Are Saying About this Episode:

The Link Between Autophagy and Ketone Synthesis

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Autophagy is needed to initiate the ketone synthesis, at least in mice! ____________________________ Scientists in Japan 🇯🇵 published this recent report in animals to help figure out the relationship between autophagy and glucose and ketone synthesis. They found that when liver-specific autophagy genes were deleted from the mice 🐁, ketone levels were significantly reduced upon fasting compared to control mice. This suggested that autophagy genes, and their related protein products, are involved in ketone synthesis. It’s likely premature in humans to say that if you’re in nutritional ketosis, your autophagy genes are upregulated. However, we do have one human clinical trial in women to lean on; which found that regular exercise increased autophagy genes 🧬. Cool stuff, eh? (For nerds, we discussed these studies in a recent podcast in iTunes and streamed on YouTube 🎥.) #autophagy #ketoaf #ketodiet #ketogenicdiet #fasting #intermittentfasting #science #muscle #fitness #exercise #postworkout #bodybuilding #mitochondria

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References Mentioned:


 The Cellular, Molecular, and Physiological Aspects of Autophagy
Levine, B., & Kroemer, G. (2008). Autophagy in the Pathogenesis of Disease. Cell, 132(1), 27–42.




Levine, B., & Kroemer, G. (2008). Autophagy in the Pathogenesis of Disease. Cell, 132(1), 27–42.

Takagi, A., Kume, S., Kondo, M., Nakazawa, J., Chin-Kanasaki, M., Araki, H., et al. (2015). Mammalian autophagy is essential for hepatic and renal ketogenesis during starvation. Scientific Reports, 1–9.


*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

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