Autophagy, Fasting and the Ketogenic Diet: Science and Updates

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[0:01] Will coffee kick you uut of a fast
[3:00] What factors influence autophagy
[4:30] What does autophagy do
[6:30] Metabolic monday- kickstarting your week with a fast
[7:30] How fasting can enhance alertness and focus
[14:00] Autophagy Is Your Cell's Mechanism to Both Take Out the
[15:30] The Autophagy Genes in Health and Disease
[16:04] Autophagy Pathways and Ketone Synthesis
[18:21] What Foods or Compounds Enhance or Potentially Decrease Autophagy
[19:00] Major Triggers of Autophagy Related Biochemical Pathways
[19:41] How Insulin May Inhibit Autophagy Signalling
[22:40] Summary of Mediators and Influencers of Autophagy Related Pathways
[11:49] Exercise and Autophagy

Tools That May Help Support Healthy Glucose and Lipid Metabolism* During Fasting and Ketosis:

Berberine HCL + ALA Complex | 500 mg of Berberine Per Serving

What Others Are Saying About this Episode:

Cellular remodeling.
Recycling.
Autophagy, Mitophagy, Macrophagy??
Huh?

Friend @MikeMutzel of #highintensityhealth Vlog speaks on it Via @YouTube

Excellent. Learn up human🤘🏼👌🏼https://t.co/pPpijXJQAS

— DYLΛN (@fysiologik) January 27, 2019

The Link Between Autophagy and Ketone Synthesis

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Autophagy is needed to initiate the ketone synthesis, at least in mice! ____________________________ Scientists in Japan 🇯🇵 published this recent report in animals to help figure out the relationship between autophagy and glucose and ketone synthesis. They found that when liver-specific autophagy genes were deleted from the mice 🐁, ketone levels were significantly reduced upon fasting compared to control mice. This suggested that autophagy genes, and their related protein products, are involved in ketone synthesis. It’s likely premature in humans to say that if you’re in nutritional ketosis, your autophagy genes are upregulated. However, we do have one human clinical trial in women to lean on; which found that regular exercise increased autophagy genes 🧬. Cool stuff, eh? (For nerds, we discussed these studies in a recent podcast in iTunes and streamed on YouTube 🎥.) #autophagy #ketoaf #ketodiet #ketogenicdiet #fasting #intermittentfasting #science #muscle #fitness #exercise #postworkout #bodybuilding #mitochondria

A post shared by Mike Mutzel, MS (@metabolic_mike) on Jan 26, 2019 at 11:08am PST

References Mentioned:

The Cellular, Molecular, and Physiological Aspects of Autophagy

Levine, B., & Kroemer, G. (2008). Autophagy in the Pathogenesis of Disease. Cell, 132(1), 27–42. http://doi.org/10.1016/j.cell.2007.12.018

Takagi, A., Kume, S., Kondo, M., Nakazawa, J., Chin-Kanasaki, M., Araki, H., et al. (2015). Mammalian autophagy is essential for hepatic and renal ketogenesis during starvation. Scientific Reports, 1–9. http://doi.org/10.1038/srep18944

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

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