Cancer is the second leading cause of death in the US, claiming some 600,000 lives annually. Historically cancer was thought to be caused by genetic mutations, but a new paradigm suggests cancer has metabolic origins. Glucose metabolism and mitochondrial function are important regulators of the tumor microenvironment.
That is: your nutrition habits and lifestyle have a huge influence on cancer risk and mortality. This video offers a deeper into the links between glucose metabolism and cancer:
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References:
Dang, C. V. Links between metabolism and cancer. Genes & Development 26, 877–890 (2012).
Dang, C. V. Links between metabolism and cancer. Genes & Development 26, 877–890 (2012).
Time Stamps:
00:00 Breast, lung, colon, and brain cancer have been linked with deranged cellular metabolism.
00:27 Cancer is the second leading cause of mortality in the US.
01:00 Normal cells aerobically breakdown carbohydrates and fats to create ATP.
01:50 Cancer cells, in the presence of oxygen, ferment glucose to make pyruvate and lactate.
03:10 Mitochondria regulate preprogrammed cell death.
05:10 Dysregulated glucose metabolism fosters a tumor microenvironment that favors expansive growth.
05:35 PET scan is diagnostic imaging tool which uses a radioisotope glucose, fluorodeoxyglucose, that helps to diagnose cancer.
07:00 Metformin, which decreases glucose, is being used in cancer treatment and therapeutics.
09:10 Tumors require a chronic overexpression of lactate. Exercise is a transient acute increase in lactate.10:04 Lactate can cause a cascade of events which helps the tumor grow more blood vessels.
11:25 By circumventing mitochondria for energy, it’s ability to induce apoptosis is inhibited.
13:00 Your microenvironment can foster or inhibit the growth of a tumor.
14:45 Cold immersion is a mitochondrial therapy.
15:40 There is an association with a lower risk for breast cancer, total cancers and colorectal cancers for people who follow dietary prevention guidelines.
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