Cardiovascular disease

Omega-6 Seed Oils: Top Reasons to Avoid Especially if You’re Low-Carb

by Mike Mutzel


As discussed previously, ApoB and other component of LDL-cholesterol are prone to oxidation and modification, which is known to initiate the process of atherosclerosis leading to heart disease.

Evidence suggests diets rich in omega-6 seed oils increase LDL susceptibility to oxidation.

Here’s the science:


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DiNicolantonio, J. J. & O’Keefe, J. H. Omega-6 vegetable oils as a driver of coronary heart disease: the oxidized linoleic acid hypothesis. Open Hear 5, e000898 (2018).



01:00 Industrial seed oils make your LDL more prone to oxidation.

02:00 Omega 6 linoleic acid is from vegetable oil.

03:20 The half life of linoleic acid in fat tissue is about 2 ½ years.

05:30 There is a link between consuming omega 6 vegetable oils and heart disease.

06:30 Linoleic acid is in higher concentrations in people with coronary artery disease.

06:45 LDL must be oxidized for the development of atherosclerosis.

08:25 Oxidation of LDL is initiated by the oxidation of linoleic acid contained within the LDL particles.

09:25 Oxidized LDL is toxic to endothelial cells of your cardiovascular system and more.

10:20 A diet higher in oleic acid, decrease LDL susceptibility to oxidation.

11:00 Oxidized LDL creates secondary product that that causes damage within the vessels.

11:08 When saturated fat plus trans fat is replaced with omega 6 vegetable oils, there is an increase in all cause mortality and cardiovascular mortality.

13:05 Exposure of the endothelium to linoleic acid is an initial step in the creation of atherosclerosis.

13:30 Consuming more linoleic acid increases the amount of linoleic acid within the aortic plaques.

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