NAC, Glutathione & Aging: New Study is Impressive

by Mike Mutzel

1 comment

NAC has been a popular amino acid to help support glutathione (GSH) synthesis and detoxification of environmental toxins and pollutants*.
But the formation of glutathione (GSH), requires both cysteine (from NAC) and glycine.

Evidence from recent human trials support the idea of a ‘GlyNAC' combo over just NAC-alone or GSH-alone when it comes to maintaining healthy GSH levels and mitochondrial function.

Here’s a review of this recent research:


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Studies Mentioned:


Kumar, P. et al. Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial. Journals Gerontology Ser 78, 75–89 (2022).

Sekhar, R. V. GlyNAC Supplementation Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Aging Hallmarks, Metabolic Defects, Muscle Strength, Cognitive Decline, and Body Composition: Implications for Healthy Aging. J Nutrition 151, nxab309- (2021).

Kumar, P. et al. Severe Glutathione Deficiency, Oxidative Stress and Oxidant Damage in Adults Hospitalized with COVID-19: Implications for GlyNAC (Glycine and N-Acetylcysteine) Supplementation. Antioxidants 11, 50 (2021).

Episode Time Stamps


00:00 Glutathione is one of your body’s most important antioxidant and detox molecules.

00:30 Supplement with raw materials, instead of directly supplementing with glutathione.

01:00 N-acetylcysteine and glycine are rate limiting amino acids in glutathione production.

01:00 Glutathione is comprised of glutamine, cystine, and glycine.

02:40 Glycine-NAC supplementation improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, ageing hallmarks, metabolic defects, muscle strength, cognitive decline and body composition.

05:20 Taking direct antioxidants has conflicting evidence.

07:30 GGT liver enzyme is a marker of glutathione turnover.

11:00 Take antioxidant supplements in the evening.

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

  1. Mike you continually have great info and insight to optimal heath, I really appreciate what you do, now I will start taking NAC and glycine at night rather than in the morning before my work out.

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