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Mike Mutzel, MS
#254 Bonus: Intermittent Fasting VS Calorie Restriction- A review of the Research
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Key Time Stamps and Takeaways
n01:08 Ketones made by your liver affect your body metabolically and epigenetically. It is like a software update for your metabolism.
01:55 You can get into ketosis with low carb diets, exercise, fasting or time-restricted feedings.
03:00 Autophagy is part of being in a fat-adapted state.
03:54 Ketosis is not starvation.
05:02 It is difficult to burn body fat for fuel when we eat 5 or 6 times a day and have an extended feeding window.
06:04 Burning fat for energy is more efficient than burning carbs, producing less metabolic and oxidative stress.
07:07 The ketogenic diet mimics the metabolic effects of calorie restriction: glucose deprivation, reduced insulin and IGF1 signaling, reduced mTOR signaling.
07:20 The diet is linked with less incidence of cancer, neoplasm and growths, as well as less chronic inflammatory disease.
07:53 Calorie restriction causes adaptive thermogenesis, the decrease in the body’s resting metabolic rate.
08:18 The resting metabolic rate from the ketogenic state or calorie restriction is not depressed in the post-weight loss window.
09:09 Ketosis is better for your liver. When you eat a lot of carbs, your liver undergoes de novo lipogenesis (DNL) and accumulates fat.
09:43 In ketosis, your liver takes fat from the liver and makes ketones.
09:55 Fat burning preserves the NAD/NADH ratio. It preserves your cellular battery.
12:44 The ketogenic diet includes high polyphenolic fruits and vegetables.
14:49 Our cell membranes are mostly fat. Omega 3s enhance the fluidity of your cell membranes.
Thank you for your articulate explanation. It is very pleasing listening to you and I agree wholeheartedly with your perspective. Perhaps Jillian is responding to her ulterior motive concerning her sponsors.
Thanks for the feedback, Pamela!
Have a lovely day,
Mike
Very much enjoyed this podcast. Thanks. Can you provide the link for that study out of the Colorado Med School (about RMR from CR vs TRF)..