The consensus in the medical community about how dietary cholesterol impacts serum low-density lipoprotein cholesterol (LDL-C) is finally shifting.
Cholesterol syntheses (by your body) contributes three times more cholesterol to the total body pool than does the absorption of dietary cholesterol. In fact, low-cholesterol diets actually increase cholesterol synthesis…
Moreover, high-cholesterol foods like eggs and red meat, have a negligeable impact on serum LDL and total cholesterol, according to this new systematic review.
So what’s increasing LDL and total cholesterol, you ask? Poor metabolic and obesity.
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Bonilha, I. et al. The Reciprocal Relationship between LDL Metabolism and Type 2 Diabetes Mellitus. Metabolites 11, 807 (2021).
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1:10 Insulin regulates the enzyme that synthesizes endogenous cholesterol.
1:50 Dietary cholesterol does not have a significant impact on serum cholesterol.
2:45 Carbohydrates increase LDL and total cholesterol and insulin.
3:30 Cholesterol has powerful benefits.
5:00 Low cholesterol diets can increase endogenous production of cholesterol and the expression of LDL receptors.
5:40 High cholesterol diet expresses fewer LDL receptors.
8:00 Eggs and meat consumption has a minimal impact on serum cholesterol.
8:53 Increased LDL cholesterol may be from of increased fat metabolism.
10:30 Type 2 diabetes and insulin resistance modifies LDL particles to be smaller and denser and more likely to become atherogenic.
13:50 Diabetes can be a side effect of Statin drugs.
14:20 Cholesterol is used to make bile.
16:20 A diet rich in seed oils may foster the modification of LDL cholesterol that can make the atherogenic.
17:45 LDL cholesterol has antiviral properties.
19:30 Insulin resistance and physical inactivity increase triglyceride production, leading to the formation of fats in the liver and elevated triglycerides and elevated vLDL cholesterol.