Cardiovascular disease

Vitamin K2 Prevents Arterial Calcification: Must Know Science

by Mike Mutzel

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Vitamin K2 is an essential fat soluble nutrient that's vital for health of your cardiovascular system, playing an important role in preventing arterial calcification, research shows.

 

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Time Stamps:

00:00 Vitamin K2 plays a role in preventing arterial calcification.

02:14 Long-term use of Warfarin, a vitamin K2 antagonist, increases calcification in the heart.

03:04 Matrix GLA proteins (MGP) are dependent upon K2 for activation.

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06:39 Triage Theory

07:49 Eat fermented foods, organ meats, and natto.

08:14 Vitamin K reduces the formation of hydroxyapatite in blood vessel smooth muscle cells.

08:44 Plants only make vitamin K1, which does not activate MGP.

11:29 Insufficient vitamin K2 intake can be from a diet of processed foods, and/or a diet without fermented foods, raw dairy, yogurt, liver, or meat-based products.

12:34 K2 supplement dose is between 45 mcg and 90 mcg (MK7 form preferred).

13:39 K2-dependent proteins are markers for various disease states.

 

References:

 

Hasific, S. et al. Extent of arterial calcification by conventional vitamin K antagonist treatment. Plos One 15, e0241450 (2020).
Theuwissen, E., Smit, E. & Vermeer, C. The Role of Vitamin K in Soft-Tissue Calcification. Adv Nutr 3, 166–173 (2012).
Poterucha, T. J. & Goldhaber, S. Z. Warfarin and Vascular Calcification. Am J Medicine 129, 635.e1-635.e4 (2016).
Elango, K. et al. The Effects of Warfarin and Direct Oral Anticoagulants on Systemic Vascular Calcification: A Review. Cells 10, 773 (2021).

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