#56: Russell Jaffe, MD PhD – Glutathione, Metallothionein and Vitamin C: key detox molecules

by Mike Mutzel


About Russell Jaffe, MD PhD

Russell Jaffe has had the privilege of contributing to the “birth” of modern integrative medicine. He works from first principles of biology to clarify the causal mechanisms of good health and ill health. His over 100 articles and invited reviews attest to his professional contributions.

Contact Dr. Jaffe

Show Notes

02:01 Dr. Jaffe’s Journey from Traditional Medicine to the Alternative: Dr. Jaffe is an expert in integrative clinical medicine and predictive biochemistry and much more. He is about getting to the root of ill health. His traditional medical training did not include the mind/body connection. He investigated meditation and mindfulness, acupuncture, irevadic medicine, or homeopathy as a skeptic, but found that it was substantive and became a student. He believes that you are the product of what you eat, drink, think and do. It turns out that these lifestyle approaches have great impact financially and in health. The current medical system is based on sick care, but he predicts a shift to one of health and caring.

06:27 The Power of Epigenetics: We have shifted from a focus on metabolism and biochemical individuality, to epigenetics – your lifestyle, habits, and choices regarding what you eat, drink, think and do determines 92% of your lifetime health that is not genetic. A small fraction of our health is determined by our DNA and our genes.

08:30 Effects of Toxins: It is your internal adaptations that determine the effect that toxins will have on you. For example: toxic metals can be a serious problem, but if you have enough healthy metallothionein to take up and detoxify those metals, they do not stay in your body. If you have switched from this elective/protective mode into survival mode, then your body cannot devote the energy to detoxification in order to deal with the immediate crisis. We can all live longer and live better with fewer resources devoted to sickness care, by being proactive about primary prevention. We can relearn how to respond to the challenges of daily living.

10:41: How Does Metallothionein Work? Metallothionein is a protein made of two amino acids: glycine and the sulfur-containing cysteine. Metallothionein is a magnesium/zinc rich protein that gives up its magnesium or zinc and irreversibly binds to any of the toxic metals, like mercury or lead. They are then excreted from the body through sweat, stool, or urine. Dr. Jaffe believes that most physicians do not understand that metallothionein stands between most of us and toxic metal intoxication. Metallothionein is everywhere in our bodies and is measureable. When we shift to survival mode, toxic metals begin to accumulate. The same happens with persisting pollutants, volatile chemicals and the risk of exposure to radioisotopes or other environmental pollutants.

12:44 How to Upregulate Metallothionein: Dr. Jaffe believes that if you have a diet rich in sulfur foods, you can build metallothionein, if you stay alkaline and you have a balanced nutrient intake, appropriate for your lifestyle. Metallothionein is very important to our long term health and survival. Nutrition begins in the kitchen, in the cooking pot. It begins with whole foods that you consume in as whole a form as possible. GGOBE is an acronym he uses for top sulfur-rich foods. It stands for garlic, ginger, onions, brassica sprouts and eggs. One or more of these should be a staple in your diet, not a condiment. Many of us are using up our methylation-critical factors faster than they are replenished. Eat what you can digest, assimilate, and eliminate without immune burden. To determine the immune burden, with one ounce of blood, we can do 500 cell cultures accurately. With this testing and a health appraisal questionnaire, a lifestyle program can be designed for you.

16:55 Whey Protein: Whey protein is high in cysteine. Native whey protein (by counter-flow technique) is easily digested and assimilated. It is a valuable way of building glutathione. Most commercial whey protein is a mixture of whey and casein, an immunogen for many of us. Your whey product should say “Native Whey by counter-flow”.

19:22 Metallothionein and Glutathione: The purpose of both of these is to protect us. Glutathione is synthesized inside of cells. Oral glutathione may help the gut and the mucosal barrier, but it does not go to your body’s cells. Glutathione is an important intermediary in keeping oxidative stress low. If we give the precursor amino acids for glutathione production in cells, GGOBE foods or supplements that contain cysteine, methionine and we have a healthy alkaline cell with mitochondria are healthy, we can make glutathione. It shuttles electrons to prevent oxidative stress and generally improve the functional efficiency of the cell.

21:58 Mitochondria and Cell Health: Most of us think of mitochondria in connection with energy. The cell protects the mitochondria and the mitochondria give the cell ATP. The mitochondria also detoxify things like pesticides, persisting pollutants and hormone disruptors. These must be detoxified inside the mitochondria. If the mitochondria are overwhelmed, then the energetics of the cell slows and uses up Coenzyme Q10, which is the electron shuttle, impairing things further. About 2/3rds of our detoxification happens in the liver. Maybe 15% of detox happens in the kidneys. A small percentage takes place in the spleen. Some also happens in our skin. Every muscle, every cell of the body does some detoxification and utilizes mitochondria to do that.

24:50 Ascorbate and Raising Glutathione: Unlike vitamins, ascorbate does not activate catalysts. It is used directly. It is a sub straight. It is used up in the course of detoxifying, energizing and protecting the other antioxidants in the body. Ascorbate is the correct name. It is the mother protective molecule for all other protective molecules in the body. The best way to raise glutathione in the cell is to give ascorbate. The amount of glutathione that you generate is proportional to having enough ascorbate.

27:42 C-Cleanse: Quickly saturate the body with mineral ascorbate, so you have calcium, magnesium, potassium and zinc minerals along with the ascorbate. Toxins and fluid are flushed out of the body. When you have taken in the amount of ascorbate you need to protect from oxidative stress, you are also maximizing the glutathione inside the cells.

29:07 Ascorbate Dosing: Very healthy people will have a C-cleanse in less than 4 grams. Somewhat healthy people will calibrate between 4 and 10 grams. 80% of the population will need between 10 and 120 grams to cleanse. 1 in 20 people will need even more to cleanse. How much ascorbate is needed correlates to how much oxidative stress you have. The C-cleanse is a self-assessment tool. You need ¾ of the amount that caused the cleanse, spread through the day. When you quickly take in as much ascorbate as your body needs, your body pumps toxins and fluids into the rectum. It is like an internal enema. The ascorbate needs to be natural, fully buffered and fully reduced. Oddly, the amount you need may increase as the body gets over its repair deficit. Looser stools or a repeat of the C-cleanse tells you when it is time to taper down your dosage.

34:51 Predictive Biomarkers: When you look at gamma-glutamyl transpeptidase (GGT), you are looking at repaired deficit or irritation and inflammation in the biliary tree. It works as a marker, but it is not predictive because the test would need to have been done on every facet of every ethnic group and have data on 10 year survival predicting 10 year outcome based on the value of the test today. There are not many tests that qualify as predictive biomarkers. Homocysteine qualifies as both a biomarker and a predictive biomarker. We look at it directly, but should look at the homocysteine/methionine ratio. Homocysteine begins leaking from blood cells as soon as it is drawn from your body. Dr. Jaffe’s lab has developed at preservative which can keep it intact for up to 3 days. Many labs will not process a specimen for homocysteine if it is over 30 minutes old.

39:41 Methylation: Methylation is about making things and moving them around and putting them in place. If you have healthy methylation, you can repair your structural proteins. No part of your body is more than 10 years old. Most of you is much younger. The concept of us wearing out is an illusion. We lose the ability to repair because our immune system is preoccupied with defense work.

43:22 If Dr. Jaffe Had the Ear of a top American Politician: We can choose to live well at low cost. If any of us have loved ones, if any of us have parents or children, if any of us are concerned about the epidemic of neurodevelopmental delays, early senility, metabolic syndrome, obesity, diabetes and cardiovascular diseases, and preserving 8 trillion dollars in assets each year, vote in favor of health, to score prevention at the office of management and budget in the congressional budget office so prevention can finally have a seat at the table. He would put a vitamin C in their hand and wish them well.


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