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Ralph Holsworth, DO- Enzyme therapy, blood viscosity and heart disease: revealing key missing links in the prevention of #1 cause of death
About Dr. Ralph Holsworth, DO
Dr. Ralph is an active emergency room physician and integrative medicine expert specializing in proteolytic enzyme therapy and blood viscosity—a major cardiovascular disease rick factor that often goes unnoticed. In this episode you’ll learn the best proteolytic enzymes to decrease cardiovascular disease risk and recover from sports injuries and more.
Suggested reading by Dr. Ralph Holsworth
01:4 Dr. Holsworth’s Journey: During medical school Dr. Holsworth read a book called Enzymes, The Fountain of Life. He called the author, Dr. Williams an oncologist MD PhD, and developed a professional relationship. Dr. Williams introduced him to Dr. Karl Ransberger, PhD, of the German Mucos Pharmaceuticals. Shortly before his death, Dr. Ransberger mentioned nattokinase to Dr. Holsworth. Dr. Holsworth works at a rural hospital where he covers the emergency room. He also has clinic patients and admits people to the hospital. It allows him to get his research from the benchtop to the bedside. He also uses integrative therapies.
06:01 Proteolytic Enzymes: The number indicators in the name of enzymes tell exactly what it breaks off from a protein. The therapeutic enzymes are class 3, hydrolase. Anything that ends in “ase” generally means that it is an enzyme. Hydrolase enzymes break open a protein by inserting a water molecule. It is as though they have a water ax. It is a biochemical catalyst. Different enzymes do this in different ways. Most of these are endopeptidase. Endo means that they cleave inside bonds.
08:22 New Enzymes: It is common perception that enzymes are broken down by hydrochloric acid, but that is generally not the case. These enzymes are shuttled into the immune system through the gut associated lymphoid tissue, where they immediately bind to the immune system. It is the byproducts from metabolites that cause the effects of pharmaceutical drugs. Enzymes go directly into the immune system. Alpha-2 macroglobulins, also called “the enzyme bus” are a very large protein that acts like a Venus fly trap to the enzyme. It is shuttled to where it needs to be in the body.
10:50 Intelligence of Enzymes: There is an intelligence. Enzymes go directly into the immune system, assisting whatever the immune system’s major task happens to be.
11:47 The Benefits of Enzymes: It is complicated. Enzymes are called biological response modulators. They do what is needed when it needs to be done. When it is bound to the alpha-2 macroglobulin, it goes from a slow stage to a fast stage, meaning it is taking the garbage out constantly. It has a significant direct and indirect affect upon the immune system.
13:17 Post Injury Inflammation: As an ER doctor, Dr. Holsworth has turned away from NSAIDs. He has trained in prolotherapy. The inflammatory process is a success story that has evolved with us and is why we are here today. Taking enzymes pushes you through the inflammatory process, cutting your healing time by about 50%. Bromelain is what he usually recommends.
14:56 Serrapeptase Enzyme: It is an amazing enzyme. It is a mucolytic, used with chronic sinusitis, COPD, reactive airway diseases, and bronchiectasis. In Japan, a form of serrapeptase is combined with an antibiotic specifically for sinusitis. It enhances the availability of the antibiotic by penetrating the sinuses.
16:05 Nattokinase: Nattokinase is used in two ways. There is a preventative modality and a therapeutic clot busting modality. Maximum clot busting capacity in your bloodstream peaks around 6 hours after oral introduction. For high risk patients, Dr. Holsworth recommends that they dose 4 times a day, particularly at bedtime due to PAI-1. As plasminogen activator inhibitor-1 increases, more people have heart attacks. Black Monday is the phenomena where a higher statistical proportion of males have acute MI heart attacks on Monday. A lot of this is secondary to max inflammation, parasympathetics and elevated PAI-1.
18:25 Impacts of Nattokinase on Blood: Nattokinase effects levels of PAI-1 and viscosity of blood. Nattokinase chews up your cross linked fibrin. About 10% is chewing on the clot. Nattokinase up regulates in synergy your PAI-1, urokinase, and plasmin, enzymes that your body creates. It places your body into a defensive mode to break up any clot that may form. PAI-1 inhibits plasminogen activation. PAI-1 is linked to sleep apnea, diabetes, belly fat, and inflammation, which makes blood more viscous. This increases risk for cerebral vascular and cardiovascular diseases.
21:37 Blood Viscosity: There are over 300 independent cardiac risk factors. The common denominator in each is whole blood viscosity. It is a more sensitive an indicator than if a patient smokes or does not. Dr. Holsworth applied his experience running a nuclear reactor in the navy to the human circulatory system. Blood is a non-Newtonian fluid, when you put shear into it, it changes. Blood is similar to ketchup in a bottle. It stays where it is when you put it upside down, unless you have it a jerk/shear. Between the relax stages and squeezing stages of the heart, blood thickens 4 to 6 fold. The physics of the blood contributes to atherogenesis. The starting line for genesis of plaque formation is in the bloodstream. Once blood becomes thick, it causes sterile inflammation on the endothelium for endothelial dysfunction.
24:37 Nattokinase and Blood Viscosity: Dr. Holsworth’s clinical research showed that nattokinase decreased blood viscosity by 18 to 20%. Technically, nattokinase does not thin the blood. It allows it to flow better.
26:51 Hydration: Dr. Holsworth completed a clinical trial that showed the effects of hydration in the prevention of hypertension. Hydration positively influenced the high shear blood viscosity during systole. When most people have blood clots in the heart, it is from the stickiness of the blood. During times of high blood viscosity, small dense lipoproteins act like small bee bees in sandblasting.
28:44 Cholesterol: Dr. Holsworth uses a VAP, a vertical assessment profile. It tells him low density lipoprotein particle size. Eighty percent of your cholesterol is determined by your liver function. Only a small portion is from dietary input. HDL was viewed as the good cholesterol. LDL was viewed as the bad cholesterol. It depends upon which pattern you have that determines whether it is beneficial or non-beneficial. When LDL are small dense packages of fats, they are called pattern B. Every time the heart beats, they are slamming into the inside of the arteries. It can decrease nitric oxide function, which allows your blood vessels to contract and dilate. When they become tight and resistant, hypertension goes up. LDLs in pattern A are big and fluffy. They are not damaging. Size matters. If all else was equal between two patients and it was only a pattern difference in LDL, the one with pattern B would have in increased risk of stroke/heart attack 4 fold.
34:04 Testing: For phone consults, Dr. Holsworth requires a Berkeley VAP test, blood viscosity, thyroid, vitamin D levels, and CRP as a bare minimum. He also looks at lifestyle and environmental attributes.
34:56 Blood Viscosity Test: With a prototype, Dr. Holsworth found that escalations in blood viscosity was the single best predictor that his patient was insulin resistant. He helped to bring this technology into a commercial lab with FDA approval. The American Heart Association is now giving attention to blood viscosity. Go to www.bloodflowonline.com for an archive of research on blood viscosity. It is a blood test that can save lives. Also see www.healthonvector.com.
39:38 Prevention Through Blood Donation: Dr. Holsworth wrote this article http://prf.sagepub.com/content/28/1/91 for the journal Perfusion. He reviewed the literature and found that patients that donated blood frequently decreased their overall incidence of heart attacks and strokes 88% to 90%. Statin drugs claim 18% to 22%. Statin drugs decrease blood viscosity. If you are healthy, it is good for you and good for humanity. You can donate 2 units every 4 months.