Cardiovascular disease

LDL Cholesterol Levels Fail to Explain Coronary Plaque Build-Up, This Biomarker Does

by Mike Mutzel

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Understanding the complex interplay between lipoproteins and coronary artery health reveals that HDL size and function, triglyceride levels, and lifestyle factors are far more predictive of cardiovascular risk and metabolic health than LDL levels alone.

 

 

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Studies Mentioned:

Gigante, B. et al. Lipoproteins and lipoprotein lipid composition are associated with stages of dysglycemia and subclinical coronary atherosclerosis. Int. J. Cardiol. 419, 132698 (2025).

 

Time Stamps:

00:00 LDL does not correlate with the degree of coronary artery calcium plaque.
01:02 HDL is protective against coronary artery disease and plaquing.
02:10 Triglycerides correlate with diabetes, coronary artery disease and plaquing.
03:45 HDL size is highly predictive.
05:15 LDL, vLDL, and IDL had no strong association.
08:00 LDL may be lower with prediabetes and diabetes, reflecting imbalance.
12:10 HDL is increased by lifestyle.
13:00 Plaquing is more common in diabetics.
15:47 High triglycerides increase odds of metabolic disease by 100%.
18:00 The smaller HDL particles become, the less protective they are.
19:13 Coronary artery calcium is associated with HDL size, concentration and composition.
21:20 High HDL with low triglycerides is linked with better metabolic health.
23:10 Exercise increases the size and number of your protective HDL.

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