04:08 Men as young as in their 20s come to Dr. Madeira for low testosterone interventions.
04:23 Andropause can happen at any age.
05:21 Tribulus is a sort of hormone adaptogen. Tribulus is effective in less than 5%. Some believe that it works by increasing luteinizing hormone the brain.
05:25 Total testosterone does not always translate adequate free testosterone, the stuff you actually use.
06:24 For every hour of lost sleep, men lose 5.85 nanograms per deciliter of total testosterone per hour. Testosterone is made when you sleep.
08:15 Untreated sleep apnea can become worse on hormone therapy. HRT contra-indications: certain genetics, a history of clots or pulmonary embolism, and taking the drug Warfarin.
09:52 Candidates for hormone intervention: A mostly healthy man who is eating and sleeping right, with no insulin resistance or diabetes, without liver or kidney disease, without sleep apnea.
10:20 Symptoms of low T: decreased strength, endurance and increased recovery time, as well as feeling more aches after exercise. Low libido and erectile dysfunction are red flags of testosterone deficiency, true clinical hypogonadism, cardiovascular disease or vascular disease.
14:30 When self-medicating or under the direction of a less than competent doctor, there are serious risks from testosterone supplementation. Estrogen levels can get high and convert to toxic estrogens. Toxic estrogens effect prostate cancer.
16:11 Low dose bioidentical testosterone therapy does not cause prostate cancer.
18:46 Testosterone usage is common in teens and early 20s. Symptoms include sudden growth, increased neck circumference, stretch marks from rapid muscle growth.
19:40 The approved upon range of total serum testosterone decreased again, saying that it is normal to have low testosterone.
21:05 A total testosterone of 350 nanograms per deciliter are at increased risk of all-cause mortality, heart attack, and stroke.
22:20 Lab ranges are determined by the population. As the population gets sicker, your sickness becomes normalized. What was out of range a few years ago, is within range now. Our population is becoming drastically sicker.
23:10 Mean total testosterone decreases about 200 to 250 ng/dl per decade.
24:02 Men with low testosterone are more likely to die younger, yet they think they are healthy.
24:15 Opiates, heavy metals, severe mold toxicity reduce testosterone and impede treatment. Orca toxin A causes problems with the brain, the control center of the pituitary gland. Mold can potentially influence or cause prostate cancer.
27:18 Testosterone therapy decreases your endogenous testosterone production. The longer you are on it, the more it will be decreased. There is another isoform of Clomid, a capsule, is a selective estrogen receptor modulator that tells the brain that it is not getting enough estrogen, so it tells the testes to make more testosterone. Your body converts that via aromatase to estrogens. If the testes are working, you can get more testosterone.
28:30 Physical trauma to the brain or testes can cause low testosterone.
34:23 Adrenal glands make a little testosterone.
35:10 Overtraining lowers testosterone.
39:10 Berberine does the same things as Metformin without side effects. Berberine increases bifidobacterium in the gut.
39:44 Herbal support can be high dose Korean ginseng and ashwaganda.
41:35 Dr. Madeira assess mitochondrial function via organic acids urine test. Work on diet and lifestyle.
42:54 HRT can prolong life and improve quality of life.
45:41 Cat’s claw from Mediherb is good for post-viral syndromes like reactivated mono.
52:46 There can be a desensitization with herbs. Your body gets tired of having certain pathways pushed for a period of time.
54:05 There a seasonal variation in testosterone levels. Men typically have more testosterone in the summer and less in the winter.
57:00 CJC and ipamorelin together are Dr. Madeira’s go to peptides for better sleep, better recovery, fat loss, and body composition. Peptides are a chain of amino acids, often injected. Get them from a compounding pharmacy, not a research facility. Ipamorelin is a selective growth hormone secretagogue. CJC tells the pituitary to make more growth hormone.
01:04:05 Peptides have been around for a long time in bodybuilding. Bodybuilders used Melanotan 2 to make their skin darker. Melanotan 2 is no longer available, but it was effective for mold toxicity and low libido.
01:07:58 Ipamorelin works well for women as well.
01:08:30 Some of men who think they have low testosterone, actually have growth hormone deficiency.
01:09:10 Ipamorelin does not increase cortisol, aldosterone, prolactin, or acetylcholine.
01:19:40 Thymosin alpha-1 (TA-1) is a thymus glandular extract (injection). It helps stimulate the immune system, tune it and modulate function. It has been studied and is used in cancer treatment and viral illnesses.
01:20:50 There are 400-thousand new diagnoses of Lyme disease every year.
01:28:02 Act now! Don’t wait to do something about your health later. Your health is not less important than other people or other things. Take an action in the right direction.