One characteristic of ageing is decreased secretion of the adrenal androgens, DHEA and DHEAS. Termed adrenopause, this condition is problematic people over 40 because DHEA contributes to 50% and 100% of testosterone production in men and post-menopausal women, respectively.
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00:10 Adrenopause is when your adrenals go into a state of decline.
00:30 About 75% of estrogens and androgens come from adrenals in post-menopausal women.
01:00 Adrenopause can appear as low DHEA, low cortisol, low cortisol awakening response, and low libido.
01:40 The adrenal medulla is the innermost portion of the adrenal gland.
01:45 Adrenal glands make epinephrine and norepinephrine.
02:00 The zona reticularis and zona fasciculata are where cortisol and other corticosteroids are released.
02:50 Cortisol should be high in the morning and lower at night.
03:30 Atrophy of portions of the adrenal glands can lead to adrenopause, which is linked with sub-optimal testosterone, poor immunologic responses, aberrant changes in estrogen and vaginal dryness.
05:40 DHEA is metabolized into testosterone, dihydrotestosterone, and estrogen, as well as affect immunologic health, brain tissue and other aspects of physiology.
07:10 Men should test DHEA before considering HRT.
08:10 You can test serum DHEA sulfate, the storage form of DHEA.
08:50 The DUTCH plus complete tests your cortisol awakening response, DHEA, melatonin, estrogen metabolites and progesterone.
09:45 Supplement timing: You may supplement adrenal glandulars and thyroid extracts in the morning and DHEA in the evening.
11:10 General dosing: men – 10 mg/decade of life, women – 2.5mg/decade of life
11:45 Insulin resistance can increase levels of androgens with DHEA supplementation.
12:20 Exposure to morning sunlight and evening sunlight can stimulate your cortisol awakening response.
12:45 The amplitude and intensity of your circadian clock system becomes muted as you age.