Longevity Scientist: Top Strategies for Improving Aging w/ Matt Kaeberlein, PhD

Matt Kaeberlein, PhD, CEO of Optispan, discusses the significance of enhancing health span through interventions like rapamycin and highlights the role of senescent cells in chronic inflammation and age-related diseases. He underscores the importance of integrating lifestyle factors such as nutrition, exercise, and sleep with ongoing research to better understand aging mechanisms and improve longevity.

 

 

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Connect with Matt:

www.optispan.life

Research Mentioned:

Kaeberlein, T. L. et al. Evaluation of off-label rapamycin use to promote healthspan in 333 adults. GeroScience 45, 2757–2768 (2023).

Elliehausen, C. J. et al. Geroprotector drugs and exercise: friends or foes on healthy longevity? BMC Biol. 21, 287 (2023).

 

The Age of Scientific Wellness

Navigating Metabolism by Navdeep Chandel

Time Stamps:

0:00 Intro

2:44 Pillars of health: eat, sleep, move, connect.

10:30 Eating protein and exercise can turn up mTOR.

15:20 High dietary protein and resistance training preserves muscle while aging.

19:20 Longevity research is underfunded.

25:10 Obesity was rare 50 years ago.

26:25 Fasting, and time restricting eating may not increase longevity.

30:45 Smoking, sedentary life, alcohol consumption and obesity shorten lifespan.

34:40 Resveratrol is not a longevity drug.

36:45 Spermidine is an autophagy booster.

38:10 Alpha ketoglutarate, urolithin A, and NAD precursors, may increase lifespan.

42:45 Acarbose, SGLT-2 inhibitors, and estrogens can increase lifespan.

44:45 Metformin does not corelate to reduced all-cause mortality.

47:30 NAD is a co-factor required for thousands of metabolic reactions.

52:55 Some epigenetic signatures are predictive of future health outcomes.

54:17 Facial imaging using AI can predict future health outcomes.

58:17 Dunedin Pace measures the rate of aging.

59:40 Optispan looks at epigenetics, blood glycan, and immune resilience/aging.

01:04:00 Senescent cells are cells that do not do their job and refuse to die.

01:07:50 Rapamycin impacts senescent cells, autoimmunity, and inflammation.

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