Matt Kaeberlein, PhD, CEO of Optispan, discusses the significance of enhancing health span through interventions like rapamycin and highlights the role of senescent cells in chronic inflammation and age-related diseases. He underscores the importance of integrating lifestyle factors such as nutrition, exercise, and sleep with ongoing research to better understand aging mechanisms and improve longevity.
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Research Mentioned:
The Age of Scientific Wellness
Navigating Metabolism by Navdeep Chandel
Time Stamps:
0:00 Intro
2:44 Pillars of health: eat, sleep, move, connect.
10:30 Eating protein and exercise can turn up mTOR.
15:20 High dietary protein and resistance training preserves muscle while aging.
19:20 Longevity research is underfunded.
25:10 Obesity was rare 50 years ago.
26:25 Fasting, and time restricting eating may not increase longevity.
30:45 Smoking, sedentary life, alcohol consumption and obesity shorten lifespan.
34:40 Resveratrol is not a longevity drug.
36:45 Spermidine is an autophagy booster.
38:10 Alpha ketoglutarate, urolithin A, and NAD precursors, may increase lifespan.
42:45 Acarbose, SGLT-2 inhibitors, and estrogens can increase lifespan.
44:45 Metformin does not corelate to reduced all-cause mortality.
47:30 NAD is a co-factor required for thousands of metabolic reactions.
52:55 Some epigenetic signatures are predictive of future health outcomes.
54:17 Facial imaging using AI can predict future health outcomes.
58:17 Dunedin Pace measures the rate of aging.
59:40 Optispan looks at epigenetics, blood glycan, and immune resilience/aging.
01:04:00 Senescent cells are cells that do not do their job and refuse to die.
01:07:50 Rapamycin impacts senescent cells, autoimmunity, and inflammation.
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