Growth Hormone DHEA Metformin In Aging Clinical Study

by Mike Mutzel


A new clinical trial found that a combination of Growth Hormone, DHEA & Metformin helped to restore the size of the thymus gland and reverse biological age (epigenetic age via the GrimAge test).

➢ Link to study:

Fahy, G. M., Brooke, R. T., Watson, J. P., Good, Z., Vasanawala, S. S., Maecker, H., et al. (2019). Reversal of epigenetic aging and immunosenescent trends in humans. Aging Cell, 18(6), 421–12.

Next time you hear someone say, “We’re all getting older together!” around a birthday, remind them that’s not entirely true.

New testing, aka the myDNAge test, reveals our “epigenetic aging clock” that’s been characterized by Dr. Steve Horvath. This test analyses methylation patterns on more than 2,000 gene regions.

So, while we’re all aging at the same chronological time, our biological age is variable based upon our diets and lifestyles.

In fact, Dr. Horvath recently published data showing how low-dose growth hormone DHEA combined with metformin (or possibly Berberine) can actually slow down biological aging.

We discuss more about:

-Age-associated inflammation or “inflammaging” (chronic, low-grade inflammation) as the reason why you age

-How this protocol enlarges the thymus gland, which has been shown to shrink with age

-DHEA and metformin as tools to slow down age-related changes in glucose metabolism

Personally, I’ve been a huge fan of both DHEA and berberine (which functions similarly to metformin) for a long time.