ApoB

Forget LDL Cholesterol, ApoB is a Better Blood Test for Heart Attack Risk

by Mike Mutzel

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The ApoB to ApoA-1 ratio is a far better predictor of heart disease risk than LDL and it can signal increased risk years in advance, new science suggests.

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Research Mentioned:

Walldius, G. et al. Long-term risk of a major cardiovascular event by apoB, apoA-1, and the apoB/apoA-1 ratio—Experience from the Swedish AMORIS cohort: A cohort study. PLoS Med. 18, e1003853 (2021).

 

Episode Time Stamps:

 

0:20 There is a strong correlation between Apo B to A1 ratio and risk of major adverse cardiovascular events.

1:03 Higher LDL at age 65 is linked with greater odds of living to be 100.

2:10 Look at LDL in context with HDL.

2:45 Apo B to A1 ratio is a direct assessment.

3:35 Optimal Apo B to A1 is about .5.

6:00 Major cardiovascular event is preceded by high Apo B to A1 ratio up to 2 years.

7:10 The ratio is more important than each total.

10:15 Increase HDL/Apo A1 with exercise and metabolic health.

12:20 Triglyceride to HDL ratio also reflects metabolic health.

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